KA1-targeted regulatory domain mutations activate Chk1 in the absence of DNA damage
نویسندگان
چکیده
منابع مشابه
KA1-targeted regulatory domain mutations activate Chk1 in the absence of DNA damage
The Chk1 protein kinase is activated in response to DNA damage through ATR-mediated phosphorylation at multiple serine-glutamine (SQ) residues within the C-terminal regulatory domain, however the molecular mechanism is not understood. Modelling indicates a high probability that this region of Chk1 contains a kinase-associated 1 (KA1) domain, a small, compact protein fold found in multiple prote...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2015
ISSN: 2045-2322
DOI: 10.1038/srep10856